Modified release prednisone in patients with rheumatoid arthritis
نویسندگان
چکیده
منابع مشابه
Modified release prednisone in patients with rheumatoid arthritis.
Since the demonstration of the potent anti-infl ammatory and immunosuppressive effects of glucocorticoids (GCs) halfway through the previous century, GCs have been the most frequently and generally used anti-infl ammatory and immunosuppressive class of drugs in a wide spectrum of immune-mediated diseases such as systemic autoimmune diseases, including the arthritides like rheumatoid arthritis (...
متن کاملEfficacy of the switch to modified-release prednisone in rheumatoid arthritis patients treated with standard glucocorticoids.
OBJECTIVES In rheumatoid arthritis (RA), low-dose glucocorticoids (GCs) demonstrate disease-modifying potential when added to DMARDs. Modified-release (MR) prednisone taken at bedtime (released 2am) is more effective than immediate-release (IR) GC taken in the morning. METHODS In an open-label observational study, 950 RA outpatients (mean age 57 ± 13 years; 75% females) treated with GCs and D...
متن کاملEfficacy and safety of modified-release prednisone in patients with rheumatoid arthritis
The introduction of modified-release (MR) prednisone adds a drug with encouraging potential to the armamentarium of the rheumatologist. In particular, for patients experiencing a reduced quality of life due to prolonged morning stiffness, it is a promising therapeutic approach. Two clinical trials and one open-label observational study investigated the effectiveness of MR prednisone in reducing...
متن کاملPharmacokinetics of modified-release prednisone tablets in healthy subjects and patients with rheumatoid arthritis.
In rheumatoid arthritis (RA), nocturnal release of proinflammatory cytokines is not adequately counteracted by endogenous glucocorticoid and is associated with symptoms of morning stiffness and pain. Taking exogenous glucocorticoid during the night reduces morning stiffness significantly more than treatment at the conventional time in the morning, although waking to take tablets is unacceptable...
متن کاملCutaneous manifestations in patients with rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with different extra-articular manifestations. Among those extra-articular manifestations, there are significant cutaneous manifestations which may result in first admission to a dermatologist. In this article some specific and non-specific skin lesions of RA such as rheumatoid nodules, exacerbated nodules, rheumatoid vascu...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2010
ISSN: 0003-4967
DOI: 10.1136/ard.2010.132738